Generic Name:
dexmethylphenidate hydrochloride
Trade Name:
Focalin ® [Novartis]
Common Chemical Name:
alpha-phenyl-2-piperidineacetate
hydrochloride, (R,R’)-(+)-
Dosage Forms/Routes:
Tablet/oral;
Extended release capsule/oral
Major Metabolite:
d-ritalinic acid
Database Search Links:
[PubMed]
[Search PubMed for
Randomized
Controlled Trials]
[PubChem]
[PDSP Ki database]
Initial Approval:
11/13/2001
Manufacturers:
[FDA Search]
Product Insert:
[Focalin Tablet]
[Focalin XR Capsule]
Epocrates:
[Link]
Empirical Formula:
C14H19NO2•HCl
Molecular Mass:
269.77 g/mol
ADHD
Dexmethylphenidate inhibits the dopamine transporter and, to a lesser degree, the norepinephrine transporter (1). The drug offers a better therapeutic index than racemic threo-methylphenidate hydrochloride (Ritalin®) (2).
Chemical Class:
d-threo enantiomer of racemic methylphenidate hydrocholoride
2D Structure:
