Generic Name:
atomoxetine hydrochloride

Trade Name:
Strattera ® [Eli Lilly]

IUPAC Name:
N-methyl-3-(2-methylphenoxy)-
3-phenyl-propan-1-amine hydrochloride

Dosage Forms/Routes:
Capsule/oral

Major Metabolites:
4-hydroxyatomoxetine;
N-desmethylatomoxetine

Database Search Links:
[PubMed]
[Search PubMed for
Randomized Controlled Trials]
[PubChem]
[PDSP Ki database]

Initial Approval:
11/26/2002

Manufacturers:
[FDA Search]

Product Insert:
[Link]

RxList:
[Link]

Epocrates:
[Link]

Empirical Formula:
C17H22ClNO

Molecular Mass:
291.815 g/mol

Indications:
ADHD

Possible Mechanisms of Action:
Atomoxetine is a selective norepinephrine reuptake inhibitor (SNRI) (1). A major metabolite of atomoxetine, 4-hydroxyatomoxetine, is a partial agonist at kappa opioid receptors (2).

 

PubChem 2D Structure:

"3D" Structure (Requires Chime):
[Link] 


1. Bymaster FP, Katner JS, Nelson DL, Hemrick-Luecke SK, Threlkeld PG, Heiligenstein JH, Morin SM, Gehlert DR, Perry KW.
Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.
Neuropsychopharmacology 2002 Nov;27(5):699-711 [Abstract]

2. Creighton CJ, Ramabadran K, Ciccone PE, Liu J, Orsini MJ, Reitz AB.
Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial kappa-opioid agonist effect.
Bioorg Med Chem Lett. 2004 Aug 2;14(15):4083-5. [Abstract]