bipolar disorder and creativity


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(Updated 8/25/04)

Rothenberg A.
Bipolar illness, creativity, and treatment.
Psychiatr Q 2001 Summer;72(2):131-47
"There have been in recent years increasing claims in both popular and professional literature for a connection between bipolar illness and creativity. A review of studies supporting this claim reveals serious flaws in sampling, methodology, presentation of results, and conclusions. Although there is therefore no evidence for etiological or genetic linkages, it is still necessary to explain interrelationships in those creative persons suffering from the illness. Examples of the work in progress of artists with bipolar disorder, Jackson Pollock and Edvard Munch, illustrate the use of healthy and adaptive creative cognition--janusian and homospatial processes--in the former's breakthrough conception during an improvement phase in treatment leading to the development of the Abstract Expressionist Movement and in the latter's transformation of an hallucination into his famous artwork "The Scream." Treatment options that do not produce cognitive effects are important for creative persons with bipolar disorder." [Abstract]


Andreasen NC.
Creativity and mental illness: prevalence rates in writers and their first-degree relatives.
Am J Psychiatry 1987 Oct;144(10):1288-92
"Rates of mental illness were examined in 30 creative writers, 30 matched control subjects, and the first-degree relatives of both groups. The writers had a substantially higher rate of mental illness, predominantly affective disorder, with a tendency toward the bipolar subtype. There was also a higher prevalence of affective disorder and creativity in the writers' first-degree relatives, suggesting that these traits run together in families and could be genetically mediated. Both writers and control subjects had IQs in the superior range; the writers excelled only on the WAIS vocabulary subtest, confirming previous observations that intelligence and creativity are independent mental abilities." [Abstract]


Shaw ED, Mann JJ, Stokes PE, Manevitz AZ.
Effects of lithium carbonate on associative productivity and idiosyncrasy in bipolar outpatients.
Am J Psychiatry 1986 Sep;143(9):1166-9
"To determine the effect of lithium carbonate on the productivity and idiosyncrasy of written associations of euthymic outpatients with affective disorder, the authors assessed 22 patients at weekly intervals during lithium treatment, 2 consecutive weeks of placebo, and 2 consecutive weeks after lithium was resumed. Lithium discontinuation produced a significant increase in associational productivity and a demonstrable increase in associative idiosyncrasy, and restoration of lithium dose significantly reversed both effects. The results suggest that lithium may affect the underlying neuropsychological functions critical to the ability to generate associations and indicate the need for further study of lithium's effects on these and other functions that may relate to neuropsychological and creative processes." [Abstract]


Schou M.
Artistic productivity and lithium prophylaxis in manic-depressive illness.
Br J Psychiatry 1979 Aug;135:97-103
"Twenty-four manic-depressive artists, in whom prophylactic lithium treatment had attenuated or prevented recurrences to a significant degree, were questioned about their creative power during the treatment. Twelve artists reported increased artistic productivity, six unaltered productivity, and six lowered productivity. The effect of lithium treatment on artistic productivity may depend on the severity and type of the illness, on individual sensitivity, and on habits of utilizing manic episodes productively." [Abstract]

Andreasen NC, Glick ID.
Bipolar affective disorder and creativity: implications and clinical management.
Compr Psychiatry 1988 May-Jun;29(3):207-17
"Research on the relationship between creativity and mental illness is summarized, and studies documenting a relationship in writers between creativity and affective illness (particularly bipolar illness) are described. Writers have a high prevalence of affective illness, and both affective illness and creativity have increased frequency in their first-degree relatives. The clinical management of the creative individual is challenging. In general, creative individuals are most productive when their affective symptoms are under good control." [Abstract]

McDermott JF.
Emily Dickinson revisited: a study of periodicity in her work.
Am J Psychiatry 2001 May;158(5):686-90
"OBJECTIVE: Emily Dickinson, arguably one of America's foremost poets, is characterized by critics as able to capture extreme emotional states in her greatest work. Recent dating of her poems offers the periodicity of her writing as a behavior that can be examined for patterns of affective illness that may relate to these states. METHOD: The bulk of Dickinson's work was written during a clearly defined 8-year period when she was age 28-35. Poems written during that period, 1858-1865, were grouped by year and examined for annual and seasonal distribution. RESULTS: Her 8-year period of productivity was marked by two 4-year phases. The first shows a seasonal pattern characterized by greater creative output in spring and summer and a lesser output during the fall and winter. This pattern was interrupted by an emotional crisis that marked the beginning of the second phase, a 4-year sustained period of greatly heightened productivity and the emergence of a revolutionary poetic style. CONCLUSIONS: These data, supported by excerpts from letters to friends during this period of Dickinson's life, demonstrate seasonal changes in mood during the first four years of major productivity, followed by a sustained elevation of creative energy, mood, and cognition during the second. They suggest, as supported by family history, a bipolar pattern previously described in creative artists." [Abstract]

Blumer D.
The illness of Vincent van Gogh.
Am J Psychiatry 2002 Apr;159(4):519-26
"Vincent van Gogh (1853-1890) had an eccentric personality and unstable moods, suffered from recurrent psychotic episodes during the last 2 years of his extraordinary life, and committed suicide at the age of 37. Despite limited evidence, well over 150 physicians have ventured a perplexing variety of diagnoses of his illness. Henri Gastaut, in a study of the artist's life and medical history published in 1956, identified van Gogh's major illness during the last 2 years of his life as temporal lobe epilepsy precipitated by the use of absinthe in the presence of an early limbic lesion. In essence, Gastaut confirmed the diagnosis originally made by the French physicians who had treated van Gogh. However, van Gogh had earlier suffered two distinct episodes of reactive depression, and there are clearly bipolar aspects to his history. Both episodes of depression were followed by sustained periods of increasingly high energy and enthusiasm, first as an evangelist and then as an artist. The highlights of van Gogh's life and letters are reviewed and discussed in an effort toward better understanding of the complexity of his illness." [Abstract]

Lederman RJ.
Robert Schumann.
Semin Neurol 1999;19 Suppl 1:17-24
"Robert Schumann, one of the giants of early romantic music, was born in Saxony in 1810 and died in an asylum shortly after his 46th birthday. Early in life, he demonstrated extraordinary skills in both music and journalism; he remained active in both areas until his final illness. His marriage to the remarkable pianist, Clara Wieck, provided him with both much-needed emotional support and a highly effective champion of his music throughout her lengthy career. Schumann's plans to be a concert pianist were thwarted at least partially by an injury to his right hand, the nature of which has been the subject of much speculation. After considering what few facts are available, the author concludes that this may have represented focal dystonia. His compositional output waxed and waned dramatically over his professional life, reflecting to some degree his emotional state. It is considered most likely that he suffered from a major affective disorder, bipolar type. This ultimately led to a suicide attempt in February 1854, and to his eventual death in July 1856. Despite wide-spread and reasonable suspicion that he may have died from neurosyphilis, severe malnutrition from self-starvation seems more likely." [Abstract

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Recent Bipolar Disorder and Creativity Research

1) Soeiro-de-Souza MG, Dias VV, Bio DS, Post RM, Moreno RA
Creativity and executive function across manic, mixed and depressive episodes in bipolar I disorder.
J Affect Disord. 2011 Jul 16;
INTRODUCTION: Creativity is a complex construct involving affective and cognitive components. Bipolar Disorder (BD) has been associated with creativity and is characterized by a wide range of affective and cognitive symptoms. Although studies of creativity in BD have tended to focus on creativity as a trait variable in medicated euthymic patients, it probably fluctuates during symptomatic states of BD. Since creativity is known to involve key affective and cognitive components, it is plausible to speculate that cognitive deficits and symptoms present in symptomatic BD could interfere with creativity. MATERIAL AND METHODS: Sixty-seven BD type I patients medication free, age 18-35years and experiencing a maniac, mixed, or depressive episodes, were assessed for creativity, executive functioning, and intelligence. RESULTS: Manic and mixed state patients had higher creativity scores than depressive individuals. Creativity was influenced by executive function measures only in manic patients. Intelligence did not influence creativity for any of the mood episode types. CONCLUSION: We propose that creativity in BD might be linked to the putative hyperdopaminergic state of mania and be dependent on intact executive function. Future studies should further explore the role of dopaminergic mechanisms in creativity in BD. [PubMed Citation] [Order full text from Infotrieve]


2) Olugbile O, Zachariah MP
The Relationship between Creativity and Mental Disorder in an African Setting.
Mens Sana Monogr. 2011 Jan;9(1):225-37.
[PubMed Citation] [Order full text from Infotrieve]


3) Rybakowski JK, Klonowska P
Bipolar mood disorder, creativity and schizotypy: an experimental study.
Psychopathology. 2011;44(5):296-302.
Aims: Our purpose was to make an experimental assessment of the elements of creativity and the features of schizotypy in patients with bipolar disorder, compared with healthy control subjects and to investigate the effect of an acute affective episode (depressed or manic) and the features of schizotypy on the measurements of creativity. Methods: Forty patients with bipolar disorder, and 48 age- and gender-matched control subjects were studied. For the assessment of creativity the Revised Art Scale and the 'inventiveness' part of the Berlin Intelligence Structure Test (BIS) were used. The Oxford-Liverpool Inventory of Feelings and Experiences was applied for estimation of schizotypy. Results: The bipolar patients did not differ on the RAS scale from the control subjects but obtained significantly higher scores on the BIS-total as well as on the verbal part of the test. Their scores on the BIS scale during depression were significantly lower than in remission. The bipolar patients obtained significantly higher scores on all dimensions of schizotypy compared with the controls. Conclusions: These results confirm previous data showing higher scores on some creativity scales in bipolar patients compared with healthy subjects. They also corroborate a relationship between the features of schizotypy and creativity scores in bipolar patients. [PubMed Citation] [Order full text from Infotrieve]


4) Kyaga S, Lichtenstein P, Boman M, Hultman C, Lĺngström N, Landén M
Creativity and mental disorder: family study of 300 000 people with severe mental disorder.
Br J Psychiatry. 2011 Jun 8;
BACKGROUND: There is a long-standing belief that creativity is coupled with psychopathology. AIMS: To test this alleged association and to investigate whether any such association is the result of environmental or genetic factors. METHOD: We performed a nested case-control study based on Swedish registries. The likelihood of holding a creative occupation in individuals who had received in-patient treatment for schizophrenia, bipolar disorder or unipolar depression between 1973 and 2003 and their relatives without such a diagnosis was compared with that of controls. RESULTS: Individuals with bipolar disorder and healthy siblings of people with schizophrenia or bipolar disorder were overrepresented in creative professions. People with schizophrenia had no increased rate of overall creative professions compared with controls, but an increased rate in the subgroup of artistic occupations. Neither individuals with unipolar depression nor their siblings differed from controls regarding creative professions. CONCLUSIONS: A familial cosegregation of both schizophrenia and bipolar disorder with creativity is suggested. [PubMed Citation] [Order full text from Infotrieve]


5) Iszáj F, Demetrovics Z
"Unborn selves"--literature as self-therapy in Virginia Woolf's work.
Psychiatr Hung. 2011;26(1):26-35.
The connection between mental disorders and creativity in writers, poets, and other artists has been the subject of scientific interest for a long time. The aim of the present study is to examine the relationship between Virginia Woolf's bipolar disorder and her literary creativity. The authors summarize Virginia Woolf's life, family background, and the course of her illness and examine their influence on her work and creation. The authors try to present the complex process in the course of which the work of art is born with the help of the unconscious and conscious. In addition, the authors consider the effect of the development of her illness on her creativity and the way in which she integrated her experiences, anxieties, misconceptions, and hallucinations into art during decompensated depression. Based on these, the authors would like to give an insight into the writer's life and work, which can help us understand better Virginia Woolf's personality, both from artistic and psychiatric point of view. [PubMed Citation] [Order full text from Infotrieve]


6) Flaherty AW
Brain illness and creativity: mechanisms and treatment risks.
Can J Psychiatry. 2011 Mar;56(3):132-43.
Brain diseases and their treatment may help or hurt creativity in ways that shape quality of life. Increased creative drive is associated with bipolar disorder, depression, psychosis, temporal lobe epilepsy, frontotemporal dementia, Parkinson disease treatments, and autism. Creativity depends on goal-driven approach motivation from midbrain dopaminergic systems. Fear-driven avoidance motivation is of less aid to creativity. When serotonin and norepinephrine lower motivation and flexible behaviour, they can inhibit creativity. Hemispheric lateralization and frontotemporal connections must interact to create new ideas and conceptual schemes. The right brain and temporal lobe contribute skill in novelty detection, while the left brain and frontal lobe foster approach motivation and more easily generate new patterns of action from the novel perceptions. Genes and phenotypes that increase plasticity and creativity in tolerant environments with relaxed selection pressure may confer risk in rigorous environments. Few papers substantively address this important but fraught topic. Antidepressants (ADs) that inhibit fear-driven motivation, such as selective serotonin reuptake inhibitors, sometimes inhibit goal-oriented motivation as well. ADs that boost goal-directed motivation, such as bupropion, may remediate this effect. Benzodiazepines and alcohol may be counterproductive. Although dopaminergic agonists sometimes stimulate creativity, their doing so may inappropriately disinhibit behaviour. Dopamine antagonists may suppress creative motivation; lithium and anticonvulsant mood stabilizers may do so less. Physical exercise and REM sleep may help creativity. Art therapy and psychotherapy are not well studied. Preserving creative motivation can help creativity and other aspects of well-being in all patients, not just artists or researchers. [PubMed Citation] [Order full text from Infotrieve]


7) Guu TW, Su KP
Musical creativity and mood bipolarity in Robert Schumann: a tribute on the 200th anniversary of the composer's birth.
Psychiatry Clin Neurosci. 2011 Feb;65(1):113-4.
[PubMed Citation] [Order full text from Infotrieve]


8) Sabelli H, Messer J, Kovacevic L, Walthall K
Biotic patterns of heart rate variation in depressed and psychotic subjects.
Nonlinear Dynamics Psychol Life Sci. 2011 Jan;15(1):11-28.
This article presents novel quantitative methods to study R to R interval (RRI) series that identify their characteristic pattern of organization, Bios, and their variation in psychiatric illness. In this study twenty-four hour series of RRI were extracted from Holter recordings of healthy subjects (N = 74) and small groups of patients with affective depression or psychosis. These data were analyzed with recurrence and statistical methods. In all subjects, RRI series showed complexes (clusters of recurrences), such as those observed with mathematically-generated biotic series but not in chaotic or random series. RRI series from healthy persons showed diversification (increase in variance with the duration of the series analyzed), novelty (less recurrence isometry than copies randomized by shuffling), causal order (more consecutive isometry than shuffled copies), and asymmetric statistical distribution. These imprints of creative processes are characteristic of mathematical Bios, and are absent in chaos. Bios can be distinguished from random walk series by the nonrandom pattern of the series of differences between heartbeats, as well as by measures of consecutive isometry and of partial autocorrelation. These defining characteristics of Bios are significant signs of health. In comparison with healthy controls, psychiatric patient groups showed more isometry and more consecutive isometry than healthy subjects. Psychiatric patients also showed no diversification. This study highlights the process that produces heart rate variation as being non-stationary and creative (bios, not equilibrium or chaos) and causal (not stochastically generated by the coexistence of multiple factors). These results thus are significant regarding psychiatric health. [PubMed Citation] [Order full text from Infotrieve]


9) Kovács E, Simon L
[Art therapy and "art brut"].
Psychiatr Hung. 2010;25(4):323-32.
The authors in this article explor the most important steps of the development of the research on the psychopathology of expression. They introduce the development of Art Brut and it's place in art history. They deal with the characteristics of art therapy. [PubMed Citation] [Order full text from Infotrieve]


10) Srivastava S, Ketter TA
The link between bipolar disorders and creativity: evidence from personality and temperament studies.
Curr Psychiatry Rep. 2010 Dec;12(6):522-30.
Although extensive literature supports connections between bipolar disorder and creativity, possible mechanisms underlying such relationships are only beginning to emerge. Herein we review evidence supporting one such possible mechanism, namely that personality/temperament contribute to enhanced creativity in individuals with bipolar disorder, a theory supported by studies showing that certain personality/temperamental traits are not only common to bipolar disorder patients and creative individuals but also correlate with measures of creativity. Thus, we suggest based on studies using three important personality/temperament measures-the Neuroticism, Extraversion, and Openness Personality Inventory (NEO); the Myers-Briggs Type Indicator (MBTI); and the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A)-that changeable (increased TEMPS-A-cyclothymia) and at times negative (increased NEO-neuroticism) affect and open-minded (increased NEO-openness) and intuitive (increased MBTI-intuition) cognition may contribute importantly to enhanced creativity in individuals with bipolar disorder. [PubMed Citation] [Order full text from Infotrieve]


11) Sabelli H, Lawandow A
Homeobios: the pattern of heartbeats in newborns, adults, and elderly patients.
Nonlinear Dynamics Psychol Life Sci. 2010 Oct;14(4):381-410.
HRV has been found useful in the study of cardiological illness in adults and elders, as well as in monitoring prenatal health. Twenty-four hour Holter recordings of R to R intervals (RRI) in healthy newborns, adults, and elderly persons were analyzed with statistical, chaos, and recurrence methods. In persons of all ages, RRI series showed relative stability (as expected in homeostatic regulation), patterned daily changes in heart rate, evidence of causality or 'determinism' (nonrandom pattern of the series of differences), and non-periodic irregular variations within limits, suggesting chaos. In addition, novel methods of analysis reveal creative features that are absent in chaotic attractors but found in bios, a non-stationary process that is generated mathematically by recursions of bipolar feedback (chaotic bios) or by the addition of sine waves. Wavelet and recurrence plots demonstrate time-limited patterns (e.g. clustering of recurrences in organized complexes) that follow each other in time indicating temporal complexity, in contrast to the temporal uniformity of chaotic attractors and of random changes. Recurrence quantification demonstrates less recurrence isometry than copies randomized by shuffling (novelty), and more consecutive isometries than shuffled copies indicating causal order. Statistical analyses demonstrate asymmetric distribution and diversification (increase in variance with the duration of the series analyzed) in contrast to convergence to an attractor. These studies indicate that the normal pattern of HRV is both homeostatic and biotic. A biotic pattern with homeostatic features (homeobios) is generated by combining bipolar feedback with negative feedback. Chaos and bios analyses may thus be useful in clinical studies. [PubMed Citation] [Order full text from Infotrieve]


12) Holm-Hadulla RM, Roussel M, Hofmann FH
Depression and creativity - the case of the German poet, scientist and statesman J. W. v. Goethe.
J Affect Disord. 2010 Dec;127(1-3):43-9.
[PubMed Citation] [Order full text from Infotrieve]


13) Murray G, Johnson SL
The clinical significance of creativity in bipolar disorder.
Clin Psychol Rev. 2010 Aug;30(6):721-32.
Clinical implications of the high rates of creativity within bipolar disorder (BD) have not been explored. The aim of this review is to outline these implications by (i) reviewing evidence for the link between creativity and BD, (ii) developing a provisional model of mechanisms underpinning the creativity-BD link, (iii) describing unique challenges faced by creative-BD populations, and (iv) systematically considering evidence-based psychosocial treatments in the light of this review. While more research into the creativity-BD nexus is urgently required, treatment outcomes will benefit from consideration of this commonly occurring phenotype. [PubMed Citation] [Order full text from Infotrieve]


14) Galvez JF, Thommi S, Ghaemi SN
Positive aspects of mental illness: a review in bipolar disorder.
J Affect Disord. 2011 Feb;128(3):185-90.
[PubMed Citation] [Order full text from Infotrieve]


15) Tremblay CH, Grosskopf S, Yang K
Brainstorm: occupational choice, bipolar illness and creativity.
Econ Hum Biol. 2010 Jul;8(2):233-41.
Although economists have analyzed earnings, unemployment, and labor force participation for those with bipolar illness, occupational choice has yet to be explored. Psychological and medical studies often suggest an association between bipolar illness and creative achievement, but they tend to focus on eminent figures, case studies, or small samples. We seek to examine occupational creativity of non-eminent individuals with bipolar disorder. We use Epidemiologic Catchment Area data to estimate a multinomial logit model matched to an index of occupational creativity. Those with bipolar illness appear to be disproportionately concentrated in the most creative occupational category. Nonparametric kernel density estimates reveal that the densities of the occupational creativity variable for the bipolar and non-bipolar individuals significantly differ in the ECA data, and suggest that the probability of engaging in creative activities on the job is higher for bipolar than non-bipolar workers. [PubMed Citation] [Order full text from Infotrieve]


16) MacCabe JH, Lambe MP, Cnattingius S, Sham PC, David AS, Reichenberg A, Murray RM, Hultman CM
Excellent school performance at age 16 and risk of adult bipolar disorder: national cohort study.
Br J Psychiatry. 2010 Feb;196(2):109-15.
[PubMed Citation] [Order full text from Infotrieve]


17) Srivastava S, Childers ME, Baek JH, Strong CM, Hill SJ, Warsett KS, Wang PW, Akiskal HS, Akiskal KK, Ketter TA
Toward interaction of affective and cognitive contributors to creativity in bipolar disorders: a controlled study.
J Affect Disord. 2010 Sep;125(1-3):27-34.
[PubMed Citation] [Order full text from Infotrieve]


18) Becker T
["Everbody is an artist"].
Psychiatr Prax. 2010 Jan;37(1):1-2.
[PubMed Citation] [Order full text from Infotrieve]


19) Lewandowska A, Rybakowski J
[Neuropsychological aspects of the manic syndrome in the course of bipolar affective illness].
Psychiatr Pol. 2009 May-Jun;43(3):275-86.
Neuropsychological deficits in schizophrenia and affective illnesses have been a topic of increasing research interest for more than two decades. Currently, the cognitive dysfunctions are regarded as an essential element of these illnesses, occurring already in their prodromal phase, with an increment during the course of illness and with some deficits persisting also during the remission period. In schizophrenia, deficits in working memory and executive functions are most frequently demonstrated. In patients with affective illnesses, the initial research focused mainly on depression, where psychomotor slowness, deficits of attention, verbal and working memory and executive functions have been observed. It has been shown that during depression in the course of bipolar affective illness, the cognitive dysfunctions have been more marked as compared with recurrent depression. In this paper, the neuropsychological changes occurring during the period of mania and hypomania have been presented. The disturbances that have been shown most frequently include selective cognitive dysfunctions such as disturbances of attention and learning process, working memory and executive functions. During periods of mania/hypomania, the specific distortions of thinking occur ("anastrophic" thinking), as well as disturbances in the decision making process, connected with increased impulsivity. Another characteristic of the episode of elevated mood has been a change of information processing of affective type, mostly a lower ability for perception and recognition of negative emotions. Among persons with bipolar affective illness, especially during the hypomanic period, an increased level of creativity than in control persons has been observed, what may facilitate higher artistic activity. Recently, the evidence has been accumulated pointing to more severe cognitive dysfunctions in bipolar affective illness, type I (with manic states) compared with bipolar affective illness, type II (with hypomania). [PubMed Citation] [Order full text from Infotrieve]


20) Wingo AP, Wingo TS, Harvey PD, Baldessarini RJ
Effects of lithium on cognitive performance: a meta-analysis.
J Clin Psychiatry. 2009 Nov;70(11):1588-97.
[PubMed Citation] [Order full text from Infotrieve]