| Pineyro, Graciela,
Blier, Pierre
Autoregulation of Serotonin Neurons: Role in Antidepressant
Drug Action
Pharmacol Rev 1999 51: 533-591 [Full
Text] Azmitia EC.
Modern views on
an ancient chemical: serotonin effects on cell proliferation, maturation, and
apoptosis.
Brain Res Bull 2001 Nov 15;56(5):413-24
"Evolutionarily,
serotonin existed in plants even before the appearance of animals. Indeed, serotonin
may be tied to the evolution of life itself, particularly through the role of
tryptophan, its precursor molecule. Tryptophan is an indole-based, essential amino
acid which is unique in its light-absorbing properties. In plants, tryptophan-based
compounds capture light energy for use in metabolism of glucose and the generation
of oxygen and reduced cofactors. Tryptophan, oxygen, and reduced cofactors combine
to form serotonin. Serotonin-like molecules direct the growth of light-capturing
structures towards the source of light. This morphogenic property also occurs
in animal cells, in which serotonin alters the cytoskeleton of cells and thus
influences the formation of contacts. In addition, serotonin regulates cell proliferation,
migration and maturation in a variety of cell types, including lung, kidney, endothelial
cells, mast cells, neurons and astrocytes). In brain, serotonin has interactions
with seven families of receptors, numbering at least 14 distinct proteins. Of
these, two receptors are important for the purposes of this review. These are
the 5-HT1A and 5-HT2A receptors, which in fact have opposing functions in a variety
of cellular and behavioral processes. The 5-HT1A receptor develops early in the
CNS and is associated with secretion of S-100beta from astrocytes and reduction
of c-AMP levels in neurons. These actions provide intracellular stability for
the cytoskeleton and result in cell differentiation and cessation of proliferation.
Clinically, 5-HT1A receptor drugs decrease brain activity and act as anxiolytics.
The 5-HT2A receptor develops more slowly and is associated with glycogenolysis
in astrocytes and increased Ca(++) availability in neurons. These actions destabilize
the internal cytoskeleton and result in cell proliferation, synaptogenesis, and
apoptosis. In humans, 5-HT2A receptor drugs produce hallucinations. The dynamic
interactions between the 5-HT1A and 5-HT2A receptors and the cytoskeleton may
provide important insights into the etiology of brain disorders and provide novel
strategies for their treatment." [Abstract]
Stenfors
C, Ross SB.
Evidence for involvement of protein kinases in the regulation
of serotonin synthesis and turnover in the mouse brain in vivo.
J Neural Transm 2002 Nov;109(11):1353-63
"Inhibition of cAMP-dependent
protein kinase (PKA) with N-[2-methylamino)ethyl]-5-isoquinolinesulfonamide (H-8)
almost completely antagonized the increase in 5-HTP accumulation and 5-HIAA/5-HT
ratio in hypothalamus induced by NAS-181, a 5-HT(1B) receptor antagonist, but
had no effect when the mice were treated with NAS-181 together with WAY-100,635,
a selective 5-HT(1A) receptor antagonist. Inhibition of Ca(2+)-calmodulin-dependent
protein kinase (CaM kinase II) with the calmodulin antagonist N-(4-aminobutyl)-5-chloro-2-naphtalenesulfonamide
(W-13) did not antagonise the effect of NAS-181 alone, but counteracted that evoked
by the combined treatment with NAS-181 and WAY-100,635. The results indicate that
activation of tryptophan hydroxylase by reducing the tone from terminal 5-HT(1B)
receptors involves PKA whereas the depolarisation-induced activation of tryptophan
hydroxylase involves CaM kinase II. The increase in the 5-HIAA/5-HT ratio may
under the experimental conditions used suggest CaM kinase II-induced phosphorylation
of synapsin I resulting in increased 5-HT release." [Abstract]
Stutzmann, Grace E., McEwen, Bruce S., LeDoux, Joseph E.
Serotonin Modulation of Sensory Inputs to the Lateral Amygdala: Dependency
on Corticosterone
J. Neurosci. 1998 18: 9529-9538 [Full
Text]
Popoli, Maurizio, Brunello, Nicoletta, Perez, Jorge, Racagni,
Giorgio
Second Messenger-Regulated Protein Kinases in the Brain:
Their Functional Role and the Action of Antidepressant Drugs.
J
Neurochem 2000 74: 21-33 [Abstract] Mlinar, Boris, Pugliese, Anna Maria,
Corradetti, Renato
Selective inhibition of local excitatory synaptic
transmission by serotonin through an unconventional receptor in the CA1 region
of rat hippocampus
J Physiol (Lond) 2001 534: 141-158
"In the present study we demonstrate a previously undescribed inhibitory
action of 5-HT on CA1 excitatory synaptic transmission. This effect is exerted
by submicromolar concentrations of 5-HT acting through an unconventional 5-HT
receptor apparently located on axon collaterals of CA1 pyramidal neurones."
[Full
Text] Sandler, Vladislav M., Ross, William N.
Serotonin Modulates Spike Backpropagation and Associated [Ca2+]i Changes in
the Apical Dendrites of Hippocampal CA1 Pyramidal Neurons
J
Neurophysiol 1999 81: 216-224 [Full
Text] Pflieger, Jean-Francois, Clarac, Francois,
Vinay, Laurent
Postural Modifications and Neuronal Excitability
Changes Induced by a Short-Term Serotonin Depletion during Neonatal Development
in the Rat
J. Neurosci. 2002 22: 5108-5117 [Abstract]
Cardenas, Carla G., Del Mar, Lucinda P., Vysokanov, Alexander
V., Arnold, Peter B., Cardenas, Luz M., Surmeier, D. James, Scroggs, Reese S.
Serotonergic modulation of hyperpolarization-activated current in acutely isolated
rat dorsal root ganglion neurons
J Physiol (Lond) 1999
518: 507-523 [Full
Text] Inoue, Tomio, Itoh, Satsuki, Kobayashi,
Masayuki, Kang, Youngnam, Matsuo, Ryuji, Wakisaka, Satoshi, Morimoto, Toshifumi
Serotonergic Modulation of the Hyperpolarizing Spike Afterpotential in Rat
Jaw-Closing Motoneurons by PKA and PKC
J Neurophysiol 1999
82: 626-637 [Full
Text] Upton, A. L., Salichon, N., Lebrand, C.,
Ravary, A., Blakely, R., Seif, I., Gaspar, P.
Excess of Serotonin
(5-HT) Alters the Segregation of Ispilateral and Contralateral Retinal Projections
in Monoamine Oxidase A Knock-Out Mice: Possible Role of 5-HT Uptake in Retinal
Ganglion Cells During Development
J. Neurosci. 1999 19:
7007-7024 [Full
Text]
Mock, Martin, Schwarz, Cornelius, Thier,
Peter
Serotonergic Control of Cerebellar Mossy Fiber Activity by
Modulation of Signal Transfer by Rat Pontine Nuclei Neurons
J
Neurophysiol 2002 88: 549-564 [Abstract] Luca
Santarelli, Gabriella Gobbi, Pierre C. Debs, Etienne L. Sibille, Pierre Blier,
René Hen, and Mark J. S. Heath
Genetic and pharmacological
disruption of neurokinin 1 receptor function decreases anxiety-related behaviors
and increases serotonergic function
PNAS 98: 1912-1917,
January 30, 2001. [Full
Text]
Jessica L. Wood, and Andrew F. Russo
Autoregulation of Cell-specific MAP Kinase Control of the Tryptophan
Hydroxylase Promoter
J. Biol. Chem. 276: 21262-21271,
June 15, 2001. [Full
Text] SMITH, KATHARINE A., WILLIAMS, CLARE, COWEN,
PHILIP J.
Impaired regulation of brain serotonin function during
dieting in women recovered from depression
Br J Psychiatry
2000 176: 72-75 [Full
Text]
Chen, Joanne J., Vasko, Michael R.,
Wu, Xiaoping, Staeva, Theodora P., Baez, Melvyn, Zgombick, John M., Nelson, David
L.
Multiple Subtypes of Serotonin Receptors Are Expressed in Rat
Sensory Neurons in Culture
J Pharmacol Exp Ther 1998 287:
1119-1127
"The presence of 5-HT1B receptors was confirmed by the displacement
of [125I]Iodocyanopindolol binding by cyanopindolol with an IC50 of 2.43 ±
0.81 nM. 5-HT1B receptors are the predominant type of serotonin receptors labeled
by [3H]5-HT in cultured DRG neurons, representing ~60% of the specific [3H]5-HT
binding sites. In addition, 5-HT1D and 5-HT2A receptor binding was also found
in these neurons. RT-PCR analysis of RNA isolated from embryonic sensory neurons
in culture confirmed the expression of 5-HT1B, 5-HT1D and 5-HT2A receptor mRNA.
It also demonstrated the presence of 5-HT1F, 5-HT2C, 5-HT3, 5-HT4, 5-HT5A and
5-HT5B receptor mRNA and the absence of 5-HT1A, 5-HT1E, 5-HT2B, 5-HT6 and 5-HT7
mRNA." [Full
Text] |
Peroutka SJ, Howell TA.
The molecular
evolution of G protein-coupled receptors: focus on 5-hydroxytryptamine receptors.
Neuropharmacology 1994 Mar-Apr;33(3-4):319-24
"Phylogenetic comparisons
between homologous proteins can provide information on the rates of molecular
evolution of the proteins. G protein-coupled receptors are a "superfamily"
of proteins which exist in species ranging from yeast to man. Based on an analysis
of the percentage of amino acid homology between various species, the rate of
molecular evolution of G protein-coupled receptors can be estimated at approx
1% per 10 million years. Based on this assumption, the primordial 5-HT receptor
must have evolved more than 700-800 million years ago since the 3 major classes
of G protein-coupled 5-HT receptors (i.e. 5-HT1, 5-HT2 and 5-HT6 receptors) are
less than 25% homologous. 5-HT5, 5-HT7, 5-HTsnail, 5-HTdro and 5-HT1A receptors
differentiated approx 600-700 million years ago, the time period during which
vertebrates diverged from invertebrates. The mammalian 5-HT receptor subtypes
have differentiated over the past 90 million years. Thus, although a recent flurry
of "new" 5-HT receptors have appeared in the literature, the first "primordial"
5-HT receptor evolved over 750 million years ago, a date which likely predates
the evolution of muscarinic, dopaminergic and adrenergic receptor systems. This
analysis also predicts that a significant number of both mammalian and invertebrate
G protein-coupled 5-HT receptor subtypes remain to be identified." [Abstract]
Meaney, Michael J., Diorio, Josie, Francis, Darlene, Weaver, Shelley,
Yau, Joyce, Chapman, Karen, Seckl, Jonathan R.
Postnatal Handling
Increases the Expression of cAMP-Inducible Transcription Factors in the Rat Hippocampus:
The Effects of Thyroid Hormones and Serotonin
J. Neurosci.
2000 20: 3926-3935 [Full
Text] Hirst WD, Cheung NY, Rattray M, Price GW,
Wilkin GP.
Cultured astrocytes express messenger RNA for multiple
serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes
to adenylyl cyclase.
Brain Res Mol Brain Res 1998 Oct 30;61(1-2):90-9
[Abstract] Rainnie,
Donald G.
Serotonergic Modulation of Neurotransmission in the Rat
Basolateral Amygdala
J Neurophysiol 1999 82: 69-85 [Full
Text]
Bankson, Michael G., Cunningham, Kathryn
A.
3,4-Methylenedioxymethamphetamine (MDMA) as a Unique Model of
Serotonin Receptor Function and Serotonin-Dopamine Interactions
J
Pharmacol Exp Ther 2001 297: 846-852 [Full
Text]
Bou-Flores, Celine, Lajard, Anne-Marie,
Monteau, Roger, De Maeyer, Edward, Seif, Isabelle, Lanoir, Jeanne, Hilaire, Gerard
Abnormal Phrenic Motoneuron Activity and Morphology in Neonatal Monoamine Oxidase
A-Deficient Transgenic Mice: Possible Role of a Serotonin Excess
J.
Neurosci. 2000 20: 4646-4656 [Full
Text] Hery, Micheline, Semont, Alexandra, Fache,
Marie-Pierre, Faudon, Maxime, Hery, Francis
The Effects of Serotonin
on Glucocorticoid Receptor Binding in Rat Raphe Nuclei and Hippocampal Cells in
Culture
J Neurochem 2000 74: 406-413 [Abstract]
Lefebvre, Herve, Compagnon, Patricia,
Contesse, Vincent, Delarue, Catherine, Thuillez, Christian, Vaudry, Hubert, Kuhn,
Jean-Marc
Production and Metabolism of Serotonin (5-HT) by the Human
Adrenal Cortex: Paracrine Stimulation of Aldosterone Secretion by 5-HT
J Clin Endocrinol Metab 2001 86: 5001-5007 [Abstract]
Martin-Ruiz, Raul, Ugedo, Luisa, Honrubia, Maria A., Mengod,
Guadalupe, Artigas, Francesc
Control of serotonergic neurons in
rat brain by dopaminergic receptors outside the dorsal raphe nucleus
J
Neurochem 2001 77: 762-775 [Abstract] Yongqing Wang, Theresa J. Berndt, Jennifer M. Gross,
Michael A. Peterson, Mathew J. So, and Franklyn G. Knox
Effect
of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal
function
Am J Physiol Regul Integr Comp Physiol 280: R248-R254,
January 2001. [Full
Text] Placantonakis, Dimitris G., Schwarz,
Cornelius, Welsh, John P.
Serotonin suppresses subthreshold and
suprathreshold oscillatory activity of rat inferior olivary neurones in vitro
J Physiol (Lond) 2000 524: 833-851 [Full
Text] Persico, Antonio M., Mengual, Elisa, Moessner,
Rainald, Hall, Scott F., Revay, Randal S., Sora, Ichiro, Arellano, Jon, DeFelipe,
Javier, Gimenez-Amaya, Jose Manuel, Conciatori, Monica, Marino, Ramona, Baldi,
Alfonso, Cabib, Simona, Pascucci, Tiziana, Uhl, George R., Murphy, Dennis L.,
Lesch, K. Peter, Keller, Flavio
Barrel Pattern Formation Requires
Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release
J. Neurosci. 2001 21: 6862-6873 [Full
Text]
Donovan, Stacy L., Mamounas, Laura
A., Andrews, Anne M., Blue, Mary E., McCasland, James S.
GAP-43
Is Critical for Normal Development of the Serotonergic Innervation in Forebrain
J. Neurosci. 2002 22: 3543-3552 [Abstract]
Irene Westbroek, Arie van der Plas, Karien E. de Rooij,
Jenneke Klein-Nulend, and Peter J. Nijweide
Expression of Serotonin
Receptors in Bone
J. Biol. Chem. 276: 28961-28968, August
3, 2001. [Full
Text]
Kara A. Scheibner, Jacqueline De Angelis,
Stephen K. Burley, and Philip A. Cole
Investigation of the Roles
of Catalytic Residues in Serotonin N-Acetyltransferase
J.
Biol. Chem. 277: 18118-18126, May 17, 2002. [Abstract]
Sun, Qian-Quan, Dale, Nicholas
G-Proteins Are
Involved in 5-HT Receptor-Mediated Modulation of N- and P/Q- But Not T-Type Ca2+
Channels
J. Neurosci. 1999 19: 890-899 [Full
Text]
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